Épisode 50 Le retour de la Kétamine

Mathieu et Arianne discutent de la kétamine, une vielle molécule qui fait son grand retour !

Dans ce 50e épisode de FrancoFOAM, on discute principalement

  • retour sur la kétamine
  • utilisation de la kétamine en analgésie, status epilepticus et sevrage alcoolique

Les objectifs de l’épisode :

  • Décrire la pharmacocinétique et pharmacodynamie de la kétamine
  • Discuter de l’utilisation de la kétamine lors de certaines situations cliniques

Mathieu et Arianne déclarent  aucun conflit d’intérêt.

La déclaration de conflit d’intérêt des membres de l’équipe du FrancoFOAM est disponible ici

Les références :

  • Hurth KP, Jaworski A, Thomas KB, Kirsch WB, Rudoni MA, Wohlfarth KM. The Reemergence of Ketamine for Treatment in Critically Ill Adults. Crit Care Med. 2020;48(6):899-911. PMID 32317593
  • Ivani G, Vercellino C, Tonetti F. Ketamine: a new look to an old drug. Minerva Anesthesiol 2003;69:468-71 PMID 12768186
  • Benken ST, Goncharenko A. The Future of intensive Care unit Sedation: A Report of Continuous infusion Ketamine as an Alternative Sedative Agent. J Pharm Pract. 2017 oct;30(5):576-581 PMID 27139887
  • Mohrien KM, Jones GM, MacDermott JR, Murphy CV. Remifentanil, ketamine, and fospropofol: a review of alterative continuous infusion agents for sedation in the critically ill. Crit Care Nurs q 2014;37(2):137-151 PMID 24595251
  • Peltoniemi MA, Hagelberg NM, Olkkola KT, Saari TI. Ketamine: A Review of Clinical Pharmacokinetics and Pharmacodynamics in Anesthesia and Pain Therapy. Clin Pharmacokinet 2016;55:1059–1077 PMID 27028535
  • Wieruszewski PM, Leung JG, Nelson S. Ketamine use in the intensive Care unit. AACN Adv Crit Care. 2018 Summer;29(2):101-106. PMID 29875104
  • Sheikh S, Hendry P. The Expanding Role of Ketamine in the Emergency Department. Drugs 2018;78:727–735 PMID 29651740
  • April MD, Arana A, Schauer SG, et al. Ketamine Versus Etomidate and Peri-intubation Hypotension: A National Emergency Airway Registry Study [published online ahead of print, 2020 Jun 26]. Acad Emerg Med. 2020;10.1111/acem.14063. doi:10.1111/acem.14063 PMID 32592205
  • Mohr NM, Pape SG, Runde D, Kaji AH, Walls RM, Brown CA 3rd. Etomidate Use Is Associated With Less Hypotension Than Ketamine for Emergency Department Sepsis Intubations: A NEAR Cohort Study [published online ahead of print, 2020 Jun 30]. Acad Emerg Med. 2020;10.1111/acem.14070. doi:10.1111/acem.14070 PMID 32602974
  • Patanwala AE, Martin JR, Erstad BL. Ketamine for Analgosedation in the Intensive Care Unit: A Systematic Review. J intensive Care Med 2017 Jul;32(6):387-395 PMID 26647407
  • Dinis-Oliveira RJ. Metabolism and metabolomics of ketamine: a toxicological approach. Forensic Sci Res. 2017;2(1):2-10. PMID 30483613
  • Groetzinger LM, Rivosecchi RM, Bain W, et al. Ketamine Infusion for Adjunct Sedation in Mechanically Ventilated Adults. Pharmacotherapy. 2018;38(2):181-188. PMID 29193185
  • Chen JW, Wasterlain CG. Status epilepticus: pathophysiology and management in adults. Lancet Neurol 2006;5:246-56 PMID 16488380
  • Sánchez Fernández I, Goodkin HP, Scott RC. Pathophysiology of convulsive status epilepticus. Seizure. 2019;68:16-21. PMID 30170734
  • Kapur J. Role of NMDA receptors in the pathophysiology and treatment of status epilepticus. Epilepsia Open. 2018;3(Suppl Suppl 2):165-168. PMID 30564775
  • Rosati A, De Masi S, Guerrini R. Ketamine for Refractory Status Epilepticus: A Systematic Review. CNS Drugs. 2018;32(11):997-1009. PMID 30232735
  • Holtkamp M. Pharmacotherapy for Refractory and Super-Refractory Status Epilepticus in Adults. Drugs 2018;78:307–326 PMID 29368126
  • Gaspard N, Foreman B, Judd LM, et al. Intravenous ketamine for the treatment of refractory status epilepticus: a retrospective multicenter study. Epilepsia. 2013;54(8):1498-1503. PMID 23758557
  • Amengual-Gual M, Sánchez Fernández I, Wainwright MS. Novel drugs and early polypharmacotherapy in status epilepticus. Seizure. 2019;68:79-88. PMID 30473267
  • Maldonado JR. Novel Algorithms for the Prophylaxis and Management of Alcohol Withdrawal Syndromes-Beyond Benzodiazepines. Crit Care Clin 2017;33:559-599 PMID 28601135
  • Shah P, McDowell M, Ebisu R, Hanif T, Toerne T. Adjunctive Use of Ketamine for Benzodiazepine-Resistant Severe Alcohol Withdrawal: a Retrospective Evaluation. J Med Toxicol 2018 Sep;14(3):229-236. PMID 29748926
  • Pizon AF, Lynch MJ1, Benedict NJ, Yanta JH, Frisch A, Menke NB, Swartzentruber GS, King AM, Abesamis MG, Kane-Gill SL. Adjunct Ketamine Use in the Management of Severe Ethanol Withdrawal. Crit Care Med 2018; 46:e768–e771 PMID 29742583

Outil et liens intéressants

Merci de partager aux passionnés en soins critiques de votre entourage !

Poursuivez la discussion sur Twitter et Facebook

Apple Podcasts

Android

Google Podcast

Spotify

YouTube

Flux RSS

Podcast

Commentaires

Commentaires